Systemic sclerosis biomarkers discovered using mass-spectrometry-based proteomics: a systematic review.

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals

PubMedID: 24831309

Balanescu P, Ladaru A, Balanescu E, Baicus C, Dan GA. Systemic sclerosis biomarkers discovered using mass-spectrometry-based proteomics: a systematic review. Biomarkers. 2014;1-11.
Abstract Context: Systemic sclerosis (SSc) is an autoimmune disease with incompletely known physiopathology. There is a great challenge to predict its course and therapeutic response using biomarkers. Objective: To critically review proteomic biomarkers discovered from biological specimens from systemic sclerosis patients using mass spectrometry technologies. Methods: Medline and Embase databases were searched in February 2014. Results: Out of the 199 records retrieved, a total of 20 records were included, identifying 116 candidate proteomic biomarkers. Conclusion: Research in SSc proteomic biomarkers should focus on biomarker validation, as there are valuable mass-spectrometry proteomics studies in the literature.