Catalytic hydroxylation of benzene and toluene by an iron complex bearing a chelating di-pyridyl-di-NHC ligand.

Chemical communications (Cambridge, England)

PubMedID: 24840886

Raba A, Cokoja M, Herrmann WA, Kühn FE. Catalytic hydroxylation of benzene and toluene by an iron complex bearing a chelating di-pyridyl-di-NHC ligand. Chem Commun (Camb). 2014;.
This work reports on iron-catalysed hydroxylation of benzene and toluene using aqueous H2O2. While benzene is hydroxylated with a high selectivity to phenol, toluene is hydroxylated to cresols with a high selectivity for the ortho and para-position. An inverse KIE indicates the presence of a high valent Fe[double bond, length as m-dash]O species during catalysis.