Isolated poliovirus capsid protein VP1 induces a neutralizing response in rats.

Proceedings of the National Academy of Sciences of the United States of America

PubMedID: 6296837

Chow M, Baltimore D. Isolated poliovirus capsid protein VP1 induces a neutralizing response in rats. Proc Natl Acad Sci USA. 1982;79(23):7518-21.
Antibodies were raised in rats against the poliovirus type 1 capsid proteins, VP1, VP2, and VP3. Antibodies directed against VP1 from type 1 poliovirus (Mahoney) neutralized type 1 but not type 2 poliovirus. Antibodies raised against VP2 and VP3 failed to neutralize type 1 virus. Thus, VP1 appears to be a neutralizing antigen for poliovirus and in its denatured form presents to the immune system its neutralizing determinants.