Localization of temperature-sensitive transformation mutations and back mutations in the Rous sarcoma virus src gene.

Journal of virology

PubMedID: 3009882

Fincham VJ, Wyke JA. Localization of temperature-sensitive transformation mutations and back mutations in the Rous sarcoma virus src gene. J Virol. 1986;58(2):694-9.
Cloning and sequencing of two temperature-sensitive transforming mutations of Rous sarcoma virus reveal that their lesions are due to distinct but close single amino acid changes near the carboxy terminus of the v-src gene product. Back mutations to wild type result from second mutations at either nearby or distant sites.