Comment on Mechanical properties of giant liposomes compressed between two parallel plates: Impact of artificial actin shells.

Langmuir : the ACS journal of surfaces and colloids

PubMedID: 24910905

Moreno-Flores S, Benitez R. Comment on Mechanical properties of giant liposomes compressed between two parallel plates: Impact of artificial actin shells. Langmuir. 2014;.
(In lieu of an abstract, this is the article's first parragraph) Schäfer and coauthors (Langmuir 2013, 29, 10463-10474) reported an extensive study on the mechanical characterization of giant vesicles, using an scanning force microscope and an ingenious experimental strategy. By means of an appropriate mechanical model based on Yoneda's work (J. Exp. Biology 1964, 41, 893-906) the authors were able to obtain mechanical parameters of the vesicle membrane, namely the in-plane tension, s0, and the area compressibility modulus, KA, from experimental force-compression curves. Though detailed in the description of the model, the article shows little if nothing about the method of data analysis. The latter poses a non-trivial mathematical issue, which is worth not only mentioning but also optimizing to some extent. In this comment we thus aim to complement the work of the authors by introducing a mathematical procedure to calculate membrane parameters from experimental force-compression data that involves the use of reduced variables and one single curve fitting.