Broad-Spectrum Catalysts for the Ambient Temperature Anti-Markovnikov Hydration of Alkynes.

Angewandte Chemie (International ed. in English)

PubMedID: 24964738

Li L, Zeng M, Herzon SB. Broad-Spectrum Catalysts for the Ambient Temperature Anti-Markovnikov Hydration of Alkynes. Angew Chem Int Ed Engl. 2014;.
Anti-Markovnikov alkyne hydration provides a valuable route to aldehydes. Half-sandwich ruthenium complexes ligated by 5,5'-bis(trifluoromethyl)-2,2'-bipyridine are remarkably active for this transformation. In the presence of 2 mol?% metal, a wide range of functionalized aliphatic and aromatic alkynes are hydrated in high yield at ambient temperature.