It's Not Necessarily All about the Delivery in Huntington's Disease.

Neuron

PubMedID: 24991950

Parsons MP, Raymond LA. It's Not Necessarily All about the Delivery in Huntington's Disease. Neuron. 2014;83(1):6-8.
Existing models of Huntington's disease posit that deficits in BDNF delivery to the striatum contribute to atrophy and motor impairment. In this issue of Neuron, Plotkin et al. (2014) show that BDNF delivery is normal but downstream signaling via TrkB and p75 is impaired, leading to corticostriatal synaptic dysfunction.