Genetic variants in desaturase gene, erythrocyte fatty acids, and risk for type 2 diabetes in Chinese Hans.

Nutrition (Burbank, Los Angeles County, Calif.)

PubMedID: 24985009

Huang T, Sun J, Chen Y, Xie H, Xu D, Huang J, Li D. Genetic variants in desaturase gene, erythrocyte fatty acids, and risk for type 2 diabetes in Chinese Hans. Nutrition. 2014;30(7-8):897-902.
OBJECTIVE
The aim of this study was to examine the association of the genetic variants in the fatty acid desaturase (FADS) gene cluster with erythrocyte phospholipid fatty acids (PLFA), and their relation to risk for type 2 diabetes mellitus (T2DM) in Han Chinese.

METHODS
Seven hundred and fifty-eight patients with T2DM and 400 healthy individuals were recruited. The erythrocyte PLFA and single-nucleotide polymorphism were determined by standard method.

RESULTS
Minor allele homozygotes and heterozygotes of rs174575 and rs174537 had lower PL 20:4 ?-6 levels in healthy individuals. Minor allele homozygotes and heterozygotes of rs174455 in FADS3 gene had lower levels of 22:5 ?-3, 20:4 ?-6, and ?5desaturase activity in patients with T2DM. Erythrocyte membrane PL 18:3 ?-3 (P for trend = 0.002), 22:5 ?-3 (P for trend < 0.001), ?-3 polyunsaturated fatty acid (P for trend < 0.001), and ?-3:?-6 (P for trend < 0.001) were significantly inversely associated with risk for T2DM.

CONCLUSION
Genetic variants in the FADS gene cluster are associated with altered erythrocyte PLFAs. High levels of PL 18:3 ?-3, 22:5 ?-3, and total ?-3 polyunsaturated fatty acid were associated with low risk for T2DM.