Vitamin D deficiency and its correction in children with sickle cell anaemia.

Annals of hematology

PubMedID: 24981689

Wykes C, Arasaretnam A, O'Driscoll S, Farnham L, Moniz C, Rees DC. Vitamin D deficiency and its correction in children with sickle cell anaemia. Ann Hematol. 2014;.
Vitamin D deficiency is common in sickle cell anaemia (SCA, HbSS), although its significance and optimal means of correction are unknown. We conducted an audit to assess the clinical significance of 25-hydroxy vitamin D (25-OHD) deficiency in children with SCA and to evaluate two methods of vitamin D supplementation. We audited 25-OHD levels in 81 children with SCA and looked for statistical associations with biochemical, haematological and clinical parameters. In a separate group of regularly transfused children with SCA, we compared changes in 25-OHD blood concentrations following treatment with either high-dose intramuscular ergocalciferol (n?=?15) or 4 days of high-dose oral cholecalciferol (n?=?64). Ninety-one percent of children with SCA had 25-OHD levels <20 µg/L. The 25-OHD levels were negatively correlated with increasing age (P?