Significance of combined detection of p53 and FHIT in cervical carcinoma diagnosis.

European journal of gynaecological oncology

PubMedID: 24984545

Du CX, Li SQ, Wang AH, Wang Y. Significance of combined detection of p53 and FHIT in cervical carcinoma diagnosis. Eur J Gynaecol Oncol. 2014;35(3):298-300.
PURPOSE
To explore the significance of combined detection of p53 genes and fragile histidine triad (FHIT) genes in cervical carcinoma.

MATERIALS AND METHODS
Specimens taken from 161 cases invasive carcinoma, 23 cases carcinoma in situ or cervical intraepithelial neoplasia III (CIN III), 74 cases CIN I - II, 25 cases normal cervical tissue, and 32 cases tumor-adjacent tissues were processed by immunohistochemistry to determine the expression of p53 and FHIT genes. The results of the combined detection were compared for clinical diagnostic value of cervical carcinoma diagnosis.

RESULTS
The p53 gene, FHIT gene and the two genes combined examination of cervical carcinoma diagnostic sensitivity were: 65.8% (121/184), 66.3% (122/184), 90.2% (166/184), respectively. There were no significant differences between the p53 gene and the FHIT gene detected (p > 0.05). Combined detection of the two gene were more sensitivity than single detection, the difference was significant (p < 0.001). Although diagnosis specificity had dropped somewhat, no significant statistical appeared (chi2 = 0.022, p > 0.05).

CONCLUSION
Combined detection of p53 genes and FHIT genes can increase the sensitivity diagnosis and specificity diagnosis for early cervical carcinoma and precancerous lesions has a positive meaning.