FERM domain-containing unconventional myosin VIIA interacts with integrin ß5 subunit and regulates avß5-mediated cell adhesion and migration.

FEBS letters

PubMedID: 24997346

Liu Y, Guan L, Zhan J, Lu D, Wan J, Zhang H. FERM domain-containing unconventional myosin VIIA interacts with integrin ß5 subunit and regulates avß5-mediated cell adhesion and migration. FEBS Lett. 2014;.
Unconventional myosin VIIA (Myo7a) has been known to associate with hereditary deafness. Here we present a novel function of Myo7a by identifying that Myo7a directly interacts with integrin ß5 subunit and regulates cell adhesion and motility in an integrin-dependent manner. We found that Myo7a bound to the cytoplasmic tail of integrin ß5. Further, we pinpointed an integrin-binding domain at F3 of the first FERM domain and F1 of the second FERM domain. Functionally, Myo7a-induced cell adhesion and migration were mediated by integrin avß5. These findings indicated that Myo7a interacts with integrin ß5 and selectively promotes integrin avß5-mediated cell migration.