Studies on the kinetics of carbamazepine degradation in aqueous matrix in the course of modified Fenton's reactions.

Journal of pharmaceutical and biomedical analysis

PubMedID: 25049061

Karpinska A, Sokól A, Karpinska J. Studies on the kinetics of carbamazepine degradation in aqueous matrix in the course of modified Fenton's reactions. J Pharm Biomed Anal. 2014;.
The present article describes a study into the kinetics of carbamazepine degradation under influence of the standard Fenton's reagent, light-enhanced Fenton's reagent, as well as modified Fenton's systems in which iron(II) ion is replaced by Cu(I), Cu(II), Ni(II), Mn(II), Cr(III) and V(V) ions. In the course of the study it was established that V(V) ion modified Fenton's reagent was equally effective in relation to carbamazepine as the standard reagent. Parameters of both standard and modified Fenton's reagents were optimized. It was observed that an increased concentration of inorganic ions and acidic pH levels precipitated the decomposition of carbamazepine.