Polyphenols with anti-proliferative activities from penthorum chinense pursh.

Molecules (Basel, Switzerland)

PubMedID: 25076141

Huang D, Jiang Y, Chen W, Yao F, Sun L. Polyphenols with anti-proliferative activities from penthorum chinense pursh. Molecules. 2014;19(8):11045-55.
Two new polyphenols, penthorumin C (1) and 2,6-dihydroxyacetophenone-4-O- [4?,6?-(S)-hexahydroxydiphenoyl]-ß-D-glucose (2), along with four known polyphenolic acids, pinocembrin-7-O-[4??,6??-hexahydroxydiphenoyl]-ß-D-glucose(3), pinocembrin-7-O-[3??-O- galloyl- 4??,6??-hexahydroxydiphenoyl]-ß-D-glucose (4), thonningianin A (5), and thonningianin B (6) were isolated from Penthourm chinense. All compounds were evaluated for their anti-proliferative activity in HSC-T6 cells, and 2 and 5 showed significant activity, with IC50 values of 12.7 and 19.2 µM, respectively.