Ultraviolet A Irradiation Increases the Permeation of Fullerenes into Human and Porcine Skin from C60-Poly(vinylpyrrolidone) Aggregate Dispersions.

Skin pharmacology and physiology

PubMedID: 25096500

Souto GD, Pohlmann AR, Guterres SS. Ultraviolet A Irradiation Increases the Permeation of Fullerenes into Human and Porcine Skin from C60-Poly(vinylpyrrolidone) Aggregate Dispersions. Skin Pharmacol Physiol. 2014;28(1):22-30.
Aim: The purpose of this study was to characterise C60-poly(vinylpyrrolidone) (PVP) dispersions, to analyse the cutaneous absorption of fullerenes as well as to evaluate whether UVA radiation (UVA-R) could modify its permeation profile. Methods: Dispersions were characterised according to their pH, particle size, zeta potential, and morphology. Skin absorption studies were performed using porcine or human skin under UVA or sham irradiation. Results: The C60 aggregate size was 129 ± 54 nm (as determined by nanoparticle tracking analysis) and the zeta potential was -4.93 ± 1.72 mV. The C60 aggregates presented an irregular shape (as measured by transmission electron microscopy) and permeated through human and porcine skin. Conclusions: C60-PVP aggregates were adequately characterised. Human skin was less permeable than porcine skin, and the presence of UVA-R increased the C60 content up to the dermis. © 2014 S. Karger AG, Basel.