The value of placental protein 13, ß-human chorionic gonadotropin and progesterone in the prediction of abortions in threatened abortion patients.

Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology

PubMedID: 25153203

Yalçin I, Taskin S, Pabuçcu EG, Söylemez F. The value of placental protein 13, ß-human chorionic gonadotropin and progesterone in the prediction of abortions in threatened abortion patients. J Obstet Gynaecol. 2014;1-4.
The aim of this paper was to investigate the levels of maternal serum placental protein13 (PP13), beta human chorionic gonadotropin (ß-hCG) and progesterone in the prediction of abortions in threatened abortions. A total of 110 patients with a gestational age < 14 weeks were included in the study. A total of 42 patients were allocated as the study group (threatened abortion) and 68 patients were allocated as controls. A total of six abortions were observed in the study group. ß-hCG levels were significantly lower in the group with threatened abortion when compared with controls (p = 0.018). There was no statistically significant difference in regard to progesterone and PP13 levels occurred between two groups (p = 0.653 and p = 0.062, respectively). Following receiver operating characteristic (ROC) analysis, the ß-hCG parameter was found useful in differentiating abortions from the threatened abortion group (p = 0.031). PP13 and progesterone parameters in predicting abortions were not found as statistically significant (p = 0.084 and p = 0.914, respectively). This study suggests that ß-hCG measurements could be useful in predicting spontaneous abortion in women presenting with threatened abortion. Even though PP13 seems unfeasible to be used as a predictive marker for abortion, factors affecting PP13 levels should be considered along with the need for comprehensive studies including larger patient populations.