Spontaneous acetabular periprosthetic fracture in a patient continuously having zoledronic Acid.

Clinics in orthopedic surgery

PubMedID: 25177464

Tantavisut S, Tanavalee A, Thanakit V, Ngarmukos S, Wilairatana V, Wangroongsub Y. Spontaneous acetabular periprosthetic fracture in a patient continuously having zoledronic Acid. Clin Orthop Surg. 2014;6(3):358-60.
Zoledronic acid has been used for prevention of osteolytic and osteoblastic bone metastasis. This case report illustrates an undesirable consequence from prolonged usage of zoledronic acid in bone metastasis prevention. Periprosthetic acetabular fracture in a patient treated with zoledronic acid for 7 years was reported. The clinical presentation, radiographic and pathological results were described. This is a rare complication after total hip arthroplasty which should not be ignored especially in patients who received long term bisphosphonate.