CSF beta-endorphin and leu-enkephalin levels in the acute and chronic stages of cerebral infarction.

Journal of neurology

PubMedID: 2956370

Kobari M, Ishihara N, Yunoki K. CSF beta-endorphin and leu-enkephalin levels in the acute and chronic stages of cerebral infarction. J Neurol. 1987;234(5):289-91.
To investigate the role of endogenous opioid peptides in the pathophysiology of cerebral ischaemia, the CSF levels of immunoreactive beta-endorphin and leu-enkephalin in 16 patients with cerebral infarction were measured. Both the CSF beta-endorphin and leu-enkephalin levels in the acute stage of cerebral infarction were significantly higher than the values in the chronic stage. The CSF concentrations of the two peptides revealed a positive correlation in the acute but not the chronic stage. The increased endogenous opioid peptides in the CSF in the acute stage may modify the evolution of cerebral infarction.