Study on serum cytokine levels in posttraumatic stress disorder patients.

Asian Pacific journal of tropical medicine

PubMedID: 22449527

Guo M, Liu T, Guo JC, Jiang XL, Chen F, Gao YS. Study on serum cytokine levels in posttraumatic stress disorder patients. Asian Pac J Trop Med. 2012;5(4):323-5.
OBJECTIVE
To evaluate serum IL-2, IL-4, IL-6, IL-8, IL-10 and TNF-a levels in posttraumatic stress disorder (PTSD) patients.

METHODS
We utilized ELISA technology to examine cytokines such as IL-2, IL-4, IL-6, IL-8, IL-10 and TNF-a in serum from 50 well-characterized individuals with a primary DSM-IV PTSD diagnosis, and 50 age- and gender-matched healthy controls. We conservatively employed a Mann-Whitney U testing.

RESULTS
Individuals with primary PTSD had significantly elevated peripheral cytokine levels for all 6 different cytokines compared to age- and gender-matched healthy controls (all P<0.01).

CONCLUSIONS
These findings suggest that a generalized inflammatory state may be present in individuals with PTSD.