Epstein-Barr virus-activating principle in the ether extracts of soils collected from under plants which contain active diterpene esters.

Cancer letters

PubMedID: 6309360

Ito Y, Ohigashi H, Koshimizu K, Yi Z. Epstein-Barr virus-activating principle in the ether extracts of soils collected from under plants which contain active diterpene esters. Cancer Lett. 1983;19(2):113-7.
Soil samples were collected from the ground under the plants of Euphorbiaceae and Thymelaeaceae known to possess Epstein-Barr virus-activating diterpene esters. In a test system, the ether extracts of such soil samples at a concentration of 20 micrograms/ml induced Epstein-Barr virus early antigen in approximately 5-25% of the non-producer Raji cells. These findings suggest a possible interaction between plant-derived diterpene esters and the human system, and provide a new aspect in considering the cause of Epstein-Barr virus-associated diseases, particularly nasopharyngeal carcinoma.