Blood group A antigen site distribution and immunoglobulin binding in relation to red cell age.

British Journal of Haematology

PubMedID: 6189509

Smalley CE, Tucker EM. Blood group A antigen site distribution and immunoglobulin binding in relation to red cell age. Br J Haematol. 1983;54(2):209-19.
Heterogeneity of alpha antigen site density was demonstrated on individual human A1 and A2 type red cells by immunoelectronmicroscopy using haemocyanin-conjugated antiglobulin. Examination of red cells fractionated on a Percoll density gradient showed that the heterogeneity was not age-related. The presence of autologous immunoglobulin on senescent red cells was also confirmed by the same technique.