In vitro adsorption of doxorubicin hydrochloride on insoluble calcium phosphate.

Journal of pharmaceutical sciences

PubMedID: 20495

Sturgeon RJ, Flanagan C, Naik DV, Schulman SG. In vitro adsorption of doxorubicin hydrochloride on insoluble calcium phosphate. J Pharm Sci. 1977;66(9):1346-7.
The adsorption of doxorubicin hydrochloride, a potent antitumor agent, on solid tribasic calcium phosphate was studied in vitro. A Langmuir adsorption isotherm at pH 7.4 and the maximum adsorption capacity of tribasic calcium phosphate were established. Tribasic calcium phosphate was chosen as a model for solid bone samples, which are stained with doxorubicin in patients who have received long-term doxorubicin therapy.