[Antitumor effect of glycopeptides from the cell wall of Lactobacillus bulgaricus].

Biulleten' eksperimental'noi biologii i meditsiny

PubMedID: 597607

Bogdanov IG, Velichkov VT, Gurevich AI, Dalev PG, Kolosov MN. [Antitumor effect of glycopeptides from the cell wall of Lactobacillus bulgaricus]. Biull Eksp Biol Med. 1977;84(12):709-12.
The antitumor activity of "blastolysin", a preparation that consisted mainly of glycopeptide fragments of the cell wall of Lactobacillus bulgaricus, was studied. Blastolysin was found to exert a specific antitumor effect on sarcoma S-180, leukemia P-388, plasmacytoma MOPC-315, adenocarcinoma AKATOL, melanosarcoma B-16, carcinoma LIC, and spontaneous tumors in mice. It is of low toxicity, does not inhibit hemopoiesis, and its action on tumor tissue differs considerably from that of the known antitumor chemotherapeutic agents.