Pilot study of triple antiviral therapy for chronic hepatitis C in interferon alpha non-responders.

Italian journal of gastroenterology and hepatology

PubMedID: 10363198

Brillanti S, Foli M, Di Tomaso M, Gramantieri L, Masci C, Bolondi L. Pilot study of triple antiviral therapy for chronic hepatitis C in interferon alpha non-responders. Ital J Gastroenterol Hepatol. 1999;31(2):130-4.
BACKGROUND
No effective therapy exists for interferon non-responding chronic hepatitis C patients.

AIMS
Pilot study evaluating the potential efficacy and safety of triple antiviral therapy in interferon-alpha non-responders.

PATIENTS AND METHODS
Twenty consecutive adult patients with chronic hepatitis C who had failed to respond to a 6-month course of interferon alpha were randomly assigned to receive a combination of interferon alpha + oral ribavirin (double therapy), or the same combination + oral amantadine (triple therapy), for 6 months.

RESULTS
By the end of therapy, normal alanine transaminase (biochemical response) was obtained in 2 out of 10 patients on double therapy but in 7 out of 10 on triple therapy (p < 0.05), and negative serum hepatitis C virus (HCV) RNA (virological response) occurred in 1 out of 10 patients on double therapy but in 7 out of 10 patients on triple therapy (p < 0.01). Six months after therapy, biochemical response was sustained in 1 (double therapy) and 4 patients (triple therapy), respectively, and the virological response was sustained in no patient on double therapy but in 3 patients on triple therapy.

CONCLUSIONS
Triple antiviral therapy seems to be able to induce biochemical and virological responses in interferon alpha non-responders with chronic hepatitis C.