Epithelial-mesenchymal interactions in the development of salivary glands.

Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists

PubMedID: 1912140

Cutler LS, Gremski W. Epithelial-mesenchymal interactions in the development of salivary glands. Crit Rev Oral Biol Med. 1991;2(1):1-12.
The full expression of both morphogenesis and secretory cell differentiation in salivary glands is modulated or controlled, at least in part, by interactions between the salivary epithelium and the surrounding mesenchyme. Salivary gland morphogenesis and cytodifferentiation are partially linked but independently regulated processes. This presentation reviews the information that establishes the role of various extracellular matrix molecules and direct epithelial-mesenchymal interactions in the induction, control, and maintenance of morphogenesis and secretory cell differentiation in salivary glands.