Cytotoxicity and structure activity relationships of phytosterol from Phyllanthus emblica.

Fitoterapia

PubMedID: 23266735

Qi WY, Li Y, Hua L, Wang K, Gao K. Cytotoxicity and structure activity relationships of phytosterol from Phyllanthus emblica. Fitoterapia. 2013;84252-6.
Fourteen sterols (1-14), including two new sterols, trihydroxysitosterol (2) and 5a,6ß,7a-7a-acetoxysitosterol (3), were isolated from the branches and leaves of Phyllanthus emblica L. The isolated compounds and a structurally related sterol 15 from Aphanamixis grandifolia were screened for cytotoxicity in two tumor cell lines (HL-60 and SMMC-7721) and a non-tumor cell line (HL-7702) using RSB assay. Within the series of phytosterol derivatives tested, compound 15 was the most active, displaying potent cytotoxicity against HL-60 with IC(50) of 5.10µmol/L, and most of the active compounds showed selective cytotoxicity against tumor and non-tumor cell lines, especially compound 10 with a safety index of 4.42.