Sibiricasaponins A-E, five new triterpenoid saponins from the aerial parts of Polygala sibirica L.

Fitoterapia

PubMedID: 23266727

Song YL, Zeng KW, Shi TX, Jiang Y, Tu PF. Sibiricasaponins A-E, five new triterpenoid saponins from the aerial parts of Polygala sibirica L. Fitoterapia. 2013;84295-301.
Five new triterpenoid saponins, named as sibiricasaponins A-E (1-5), were isolated and identified from the aerial parts of Polygala sibirica L., together with nine known triterpenoid saponins (6-14). The chemical structures of the five new triterpenoid saponins (1-5) were elucidated as 3ß,19a-dihydroxyurso-12-ene-23,28-dioic acid 3-O-ß-d-glucuronopyranoside (1), pomolic acid 3-O-(3-O-sulfo)-a-l-arabinopyranoside (2), pomolic acid 3-O-(4-O-sulfo)-ß-d-xylopyranoside (3), pomolic acid 3-O-(2-O-acetyl-3-O-sulfo)-a-l-arabinopyranoside (4), and 3-O-ß-d-glucopyranosyl medicagenic acid 28-O-ß-d-galactopyranosyl (1?4)-ß-d-xylopyranosyl (1?4)-a-l-rhamnopyranosyl (1?2)-(4-O-acetyl)-[ß-d-apiofuranosyl (1?3)]-ß-d-fucopyranosyl ester (5), respectively, on the basis of spectroscopic data and physicochemical evidences. These isolated compounds (1-14) were evaluated for their anti-ischemic effects on oxygen/glucose deprivation (OGD) model in vitro, and only compound 7 showed a weak anti-ischemia effect, with EC(50) value of 46.7µM.