Sinoscrewtine, an alkaloid with novel skeleton from the roots of Sinomenium acutum.

Fitoterapia

PubMedID: 23103953

Wang XL, Liu BR, Chen CK, Qin GW, Lee SS. Sinoscrewtine, an alkaloid with novel skeleton from the roots of Sinomenium acutum. Fitoterapia. 2013;8454-7.
An alkaloid with novel skeleton, sinoscrewtine (1), has been isolated from the roots of Sinomenium acutum. Its structure was established by spectral analysis and X-ray crystallographic study, and its possible biosynthetic pathway was delivered. In vitro experiments, 1 showed weak injurious effects against H(2)O(2)/Aß(25-35) induced oxidative injury in PC-12 cells and DPPH radical scavenging activity with IC(50) of 32.6µM.