Selective RXR modulators for the treatment of type II diabetes.

Current opinion in drug discovery & development

PubMedID: 12478728

Faul MM, Grese TA. Selective RXR modulators for the treatment of type II diabetes. Curr Opin Drug Discov Devel. 2002;5(6):974-85.
Retinoid X receptor (RXR) modulators are being evaluated as a means for the treatment of non-insulin dependent (type II) diabetes mellitus, and substantial progress has been made in the preclinical evaluation of these compounds. To aid in this process, several structural classes of RXR modulators are now under investigation. The diverse structures and syntheses of these compounds will be discussed in this review.