Platelet reactivity and serum thromboxane B2 production in whole blood in gestational hypertension and pre-eclampsia.

British journal of obstetrics and gynaecology

PubMedID: 1777456

Louden KA, Broughton Pipkin F, Heptinstall S, Fox SC, Mitchell JR, Symonds EM. Platelet reactivity and serum thromboxane B2 production in whole blood in gestational hypertension and pre-eclampsia. Br J Obstet Gynaecol. 1991;98(12):1239-44.
OBJECTIVE
To determine the nature and extent of changes in platelet reactivity in gestational hypertension and pre-eclampsia (using whole blood techniques which may be more physiological than those previously employed).

DESIGN
Cross-sectional observational study.

SUBJECTS
8 normal primigravidae, 16 women with gestational hypertension and 12 women with pre-eclampsia, studied at around 36 weeks gestation.

RESULTS
Platelet reactivity (aggregation and release reaction) induced by stimulation with adrenaline was decreased in the pre-eclamptic group. Serum thromboxane B2 production was unchanged in both hypertensive groups compared with the control group.

CONCLUSIONS
In the context of evidence of platelet activation in pre-eclampsia, our findings are interpreted as reflecting platelet exhaustion.