A factor that can be used to regulate an in vitro primary immune response.

Proceedings of the National Academy of Sciences of the United States of America

PubMedID: 4551977

watson J, Thoman M. A factor that can be used to regulate an in vitro primary immune response. Proc Natl Acad Sci USA. 1972;69(3):594-8.
A factor has been isolated that supports the stimulation of an immune response against heterologous erythrocyte antigens in mouse spleen cells cultured in a medium that contains deficient serum. The factor is secreted by certain spleen cells that are obtained in permanent culture after leukemia virus infection. The factor permits antigen-sensitive cells derived from bone marrow to mature to antibody-forming cells. This factor can be used in controlling the initiation of a primary immune response in vitro.