Ranitidine influences the uptake of oral midazolam.

British journal of clinical pharmacology

PubMedID: 6135440

Elwood RJ, Hildebrand PJ, Dundee JW, Collier PS. Ranitidine influences the uptake of oral midazolam. Br J Clin Pharmacol. 1983;15(6):743-5.
In a randomised crossover study in volunteers plasma midazolam levels were estimated for 24 h following 15 mg by mouth, either preceded by no medication or following 24 h therapy with ranitidine. Administration of the H2-receptor blocker significantly increased bioavailability of the benzodiazepine and resulted in higher plasma levels for the first 6 h after taking midazolam. This was accompanied by a greater soporific effect.