Inhibition of murine leukemia virus replication by poly(vinyluracil) and poly(vinyladenine).

Proceedings of the National Academy of Sciences of the United States of America

PubMedID: 4123932

Pitha PM, Teich NM, Lowy DR, Pitha J. Inhibition of murine leukemia virus replication by poly(vinyluracil) and poly(vinyladenine). Proc Natl Acad Sci USA. 1973;70(4):1204-8.
Poly(1-vinyluracil) and poly(9-vinyladenine), as well as the corresponding polynucleotides poly(uridylate) and poly(adenylate), inhibit acute murine leukemia virus infection in mouse-embryo cells, but they do not significantly inhibit the replication of Sindbis and vesicular stomatitis viruses. The polymers were most effective as inhibitors when added during an early stage of virus replication. Effects of vinyl polymers on the RNA-dependent DNA polymerase from the virions of murine leukemia virus were also observed.