Thymosin-induced human serum factor increasing cyclic AMP.

Journal of Immunology (Baltimore, Md. : 1950)

PubMedID: 197166

Astaldi A, Astaldi GC, Wijermans P, Groenewoud M, Schellekens PT, Eijsvoogel VP. Thymosin-induced human serum factor increasing cyclic AMP. J Immunol. 1977;119(3):1106-8.
Thymosin has virtually no in vitro effect on cyclic AMP levels in thymocytes and seems not to react with either the beta-adrenergic receptor or with the putative human serum thymic factor (SF) receptor. However, when thymosin is injected into patients lacking SF activity, it induces the appearance of a serum factor which increases cellular cyclic AMP levels in thymocytes in vitro. This factor appears to act on a membrane site distinct from the beta-adrenergic receptors.