THE RELATIONSHIP OF CHRONIC PROTEIN INTOXICATION IN ANIMALS TO ANAPHYLAXIS.

The Journal of experimental medicine

PubMedID: 19867959

Longcope WT. THE RELATIONSHIP OF CHRONIC PROTEIN INTOXICATION IN ANIMALS TO ANAPHYLAXIS. J Exp Med. 1915;22(6):793-9.
Such foreign proteins as horse serum and egg-white in the amounts employed in these experiments do not produce evidences of intoxication immediately after injection into rabbits. Single large injections do, however, produce changes in the parenchymatous organs after a period often to twenty-one days. These develop at the time or immediately after the animal has formed antibodies for the foreign proteins. The mechanism of the development of the lesions in the myocardium, liver, and kidneys of rabbits is thus the same, whether a single inoculation is given or whether repeated inoculations are made in sensitized animals. By the latter method, however, much more marked and extensive changes may be produced.