STUDIES ON THE QUANTITATIVE ACTION OF A SPECIFIC ENZYME IN TYPE III PNEUMOCOCCUS DERMAL INFECTION IN RABBITS.

The Journal of experimental medicine

PubMedID: 19870083

Goodner K, Dubos R. STUDIES ON THE QUANTITATIVE ACTION OF A SPECIFIC ENZYME IN TYPE III PNEUMOCOCCUS DERMAL INFECTION IN RABBITS. J Exp Med. 1932;56(4):521-30.
The enzyme which specifically decomposes the capsular polysaccharide of Type III Pneumococcus must be used in certain definite amounts in order to bring about the recovery of rabbits infected intradermally with this organism. The experiments reported in this paper indicate that the minimal amounts of enzyme required bear a definite relationship to the severity of the infection as gauged by the number of pneumococci present in the circulating blood.