Reactive Oxygen Species, Granulocytes, and NETosis.

Advances in experimental medicine and biology

PubMedID: 25310939

Arazna M, Pruchniak MP, Demkow U. Reactive Oxygen Species, Granulocytes, and NETosis. Adv Exp Med Biol. 2014;.
When pathogens invade the body, neutrophils create the first line of defense. Basic weaponry consists of phagocytosis and degranulation, but these cells have yet another ace in the sleeve, a unique strategy in which invading microorganisms are being destroyed. These cellular warriors are able to release nuclear chromatin and form extracellular structure, known as neutrophil extracellular traps (NET). NET formation is connected with the presence of free radicals. Research has shown that inhibition of free radical formation leads to suppression of NET release. The exact mechanisms controlling cooperation of free radicals with NET still remain unclear. New investigations in this field may contribute to discovery of NET etiology and put a new light on related disorders.