Pathological features and prognosis of lobular carcinoma in Egyptian breast cancer patients.

Women's health (London, England)

PubMedID: 25335542

Azim HA, Malek RA, Azim HA. Pathological features and prognosis of lobular carcinoma in Egyptian breast cancer patients. Womens Health (Lond Engl). 2014;10(5):511-8.
AIM
To illustrate the differences between invasive lobular and ductal carcinomas (ILCs and IDCs) in terms of baseline demographics, pathologic features and recurrence in Egyptian breast cancer patients.

PATIENTS & METHODS
Retrospective analysis of breast cancer patients diagnosed and treated between 2000 and 2008 was performed.

RESULTS
176 (8.5%) and 1758 (85%) cases were diagnosed with ILC and IDC, respectively. Compared with IDC, ILC was less observed in patients under 35 years of age (3.4 vs 9.3%; p = 0.009), and was associated with more bilaterality (p = 0.001), advanced tumor stage (p = 0.027) and nodal involvement (p = 0.004). On the other hand, IDC was significantly associated with more luminal B-like phenotype (16.9 vs 8.1%; p < 0.001) and more HER2-enriched disease (11.5 vs 2.7%; p < 0.001). At a median follow-up time of 64 months, ILC histology was independently associated with better disease-free survival (hazard ratio: 0.58; 95% CI: 0.36-0.93; p = 0.023). Bone and peritoneal relapses were more common in ILC, while lung relapses were more common in IDC.

CONCLUSION
ILC has distinct biologic and prognostic features that may warrant different therapeutic approaches.