Association between endothelial nitric oxide synthase 894G>T polymorphism and prostate cancer risk: a meta-analysis of literature studies.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

PubMedID: 25374059

Zhao C, Yan W, Zu X, Chen M, Liu L, Zhao S, Liu H, Hu X, Luo R, Xia Y, Qi L. Association between endothelial nitric oxide synthase 894G>T polymorphism and prostate cancer risk: a meta-analysis of literature studies. Tumour Biol. 2014;.
To date, several studies have been conducted to assess the association between endothelial nitric oxide synthase (eNOS) gene 894G?>?T polymorphism and prostate cancer (PCa) risk, but the results are conflicting. To derive a more precise estimation of the relationship between 894G?>?T polymorphism and PCa risk, the present meta-analysis was performed. A total of eight case-control studies were included in this meta-analysis. The pooled odds ratio (OR) with 95 % confidence interval (CI) was calculated to evaluate the associations. Our results suggested that 894G?>?T polymorphism is associated with PCa risk under codominant (GT vs. GG) (OR?=?1.11, 95 % CI?=?1.01-1.22, P?=?0.04) and overdominant (GT vs. GG?+?TT) (OR?=?1.12, 95 % CI?=?1.02-1.23, P?=?0.02) models in the overall population, while there are no associations observed under dominant (GT?+?TT vs. GG), recessive (TT vs. GG?+?GT), and allelic (T vs. G) models. Moreover, when the eligible studies were stratified according to sources of control, significant association between 894G?>?T polymorphism and susceptibility of PCa was also identified under codominant (OR?=?1.12, 95 % CI?=?1.01-1.24, P?=?0.03) and overdominant (OR?=?1.13, 95 % CI?=?1.02-1.25, P?=?0.02) models when using healthy individuals as control. However, there are no significant associations found under any genetic models when using BPH patients as control group. In conclusion, the present meta-analysis suggested that the eNOS gene 894G?>?T polymorphism might be a risk factor in the onset of PCa.