BRCA1, a "complex" protein involved in the maintenance of genomic stability.

The FEBS journal

PubMedID: 25400280

Savage KI, Harkin DP. BRCA1, a "complex" protein involved in the maintenance of genomic stability. FEBS J. 2014;.
BRCA1 is a major breast and ovarian cancer susceptibility gene, with mutations in this gene predisposing women to a very high risk of developing breast and ovarian tumours. BRCA1 primarily functions to maintain genomic stability, through critical roles in DNA repair, cell cycle checkpoint control, transcriptional regulation, apoptosis and mRNA splicing. As a result BRCA1 mutations often result in defective DNA repair, genomic instability and sensitivity to DNA damaging agents. BRCA1 carries out these different functions through its ability to interact, and form complexes with, a vast array of proteins involved in multiple cellular processes, all of which are thought to contribute to its function as a tumour suppressor. This review will discuss and highlight recent research into the functions of BRCA1 related protein complexes and their roles in maintaining genomic stability and tumour suppression. This article is protected by copyright. All rights reserved.