Penthorin A and B, two unusual 2,4'-epoxy-8,5'-neolignans from Penthorum chinese.

Fitoterapia

PubMedID: 25447159

He Y, Zou Y, Peng C, Liu J, He C, Guo L, Xie X, Xiong L. Penthorin A and B, two unusual 2,4'-epoxy-8,5'-neolignans from Penthorum chinese. Fitoterapia. 2014;100C7-10.
Two new 2,4'-epoxy-8,5'-neolignans (1 and 2), together with five known 7,9';7',9-diepoxylignans (3-7), were isolated from an ethyl acetate soluble portion of a hepatoprotective water decoction of Penthorum chinese. Their structures and absolute configurations were elucidated by extensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. This is the second report of 2,4'-epoxy-8,5'-neolignans from plants. Compounds 2, 6, and 7 showed in vitro protective activities against acetaminophen-induced hepatocyte injury at 5┬ÁM.