Synthesis and Biological Applications of Phosphinates and Derivatives.

Topics in current chemistry

PubMedID: 25467530

Virieux D, Volle JN, Bakalara N, Pirat JL. Synthesis and Biological Applications of Phosphinates and Derivatives. Top Curr Chem. 2014;.
This review first outlines general considerations on phosphinic acids and derivatives as bioisosteric groups. The next sections present key aspects of phosphinic acid-based molecules and include a brief description of the biological pathways involved for their activities. The synthetic aspects and the biological activities of such compounds reported in the literature between 2008 and 2013 are also described.