Cardiac resynchronization therapy in heart failure patients with less severe left ventricular dysfunction.

European journal of heart failure : journal of the Working Group on Heart Failure of the European Society of Cardiology

PubMedID: 25469668

Hai OY, Mentz RJ, Zannad F, Gasparini M, De Ferrari GM, Daubert JC, Holzmeister J, Lam CS, Pochet T, Vincent A, Linde C. Cardiac resynchronization therapy in heart failure patients with less severe left ventricular dysfunction. Eur J Heart Fail. 2014;.
Cardiac resynchronization therapy is beneficial in heart failure patients with LVEF =35% and electrical dyssynchrony. However, its effects among patients with less severe LV dysfunction have not been established. Recent post-hoc analyses of landmark CRT trials suggest that CRT benefit may be present in patients with LVEF >35% and is associated with improvement in cardiac reverse remodelling, all-cause mortality, and need for heart failure hospitalizations. This review summarizes the currently available literature regarding the potential impact of CRT in patients with more modest reductions in LVEF.