Placental miR-106a~363 cluster is dysregulated in preeclamptic placenta.

Placenta

PubMedID: 25499681

Zhang C, Li Q, Ren N, Li C, Wang X, Xie M, Gao Z, Pan Z, Zhao C, Ren C, Yang W. Placental miR-106a~363 cluster is dysregulated in preeclamptic placenta. Placenta. 2014;.
Preeclampsia (PE) is the leading cause of maternal and perinatal mortality and morbidity. MicroRNAs are strongly implicated in the pathogenesis of this syndrome. In current study, we performed a microarray assay to explore miRNA expression profile in the placenta, and found 11 upregulated and 7 downregulated miRNAs in preeclampsia. miR-363, plus other 5 member of miR-106a~363 cluster was further examined and validated. These findings would facilitate further investigation of aberrant expression of miRNAs in the pathology of preeclampsia.