Lymph Node Count After Preoperative Radiotherapy Is an Independently Prognostic Factor For Pathologically Lymph Node-Negative Patients With Rectal Cancer.

Medicine

PubMedID: 25621683

Li Q, Zhuo C, Liang L, Zheng H, Li D, Cai S. Lymph Node Count After Preoperative Radiotherapy Is an Independently Prognostic Factor For Pathologically Lymph Node-Negative Patients With Rectal Cancer. Medicine (Baltimore). 2015;94(3):e395.
Recent studies indicated that preoperative radiotherapy significantly reduces the lymph nodes (LNs) harvest from patients with rectal cancer. This may weaken the prognostic value of current standard of LNs retrieval (=12 LNs). This study investigates the prognostic impact of the LN counts on pathologically LN-negative (ypN0) after preoperative radiotherapy for patients with rectal cancer.Surveillance, Epidemiology and End Results (SEER) registered nonmetastatic rectal cancer patients diagnosed between 1998 and 2005 were included in this study. Optimal cutoff value for number of LNs retrieved was determined by X-tile program. Log-rank tests were adopted to compare the rectal cause specific survival (RCSS) for ypN0 patients using separated cutoff value of LN counting from 2 to 20. Correlation between LN count and tumor regression was investigated in an additional 221 patients from Fudan University Shanghai Cancer Center (FUSCC).The results showed that there were fewer number of LNs examined in patients with preoperative radiotherapy than those without (8.9 vs 10.9, P?