Palladium-catalysed carbonylative a-arylation of nitromethane.

Chemical communications (Cambridge, England)

PubMedID: 25634329

Lian Z, Friis SD, Skrydstrup T. Palladium-catalysed carbonylative a-arylation of nitromethane. Chem Commun (Camb). 2015;.
A simple and mild Pd-catalysed carbonylative a-arylation of nitromethane has been realised providing access to a-nitro aryl ketones from an array of aryl and heteroaryl iodides. The methodology requires only a mild base and uses the convenient solid CO releasing molecule, COgen in a two-chamber system. Changing to the isotopically labelled (13)COgen, [(13)C]-acyl labelling can be effected through the generation of a near stoichiometric amount of (13)CO. Lastly, the significance of the generated products as synthetic intermediates is demonstrated.