Nasal lavage is better than blood count in predicting sputum eosinophilia.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology

PubMedID: 25675973

Amorim MM. Nasal lavage is better than blood count in predicting sputum eosinophilia. Clin Exp Allergy. 2015;.
The ERS/ATS guidelines for severe asthma evaluation recommends the use of sputum eosinophil count as biomarker to guide therapy in adults, due to it places a higher value on possible clinical benefits from adjusting the treatment. However, it is useful only for patients who can produce sputum with persistent or, at least, intermittent eosinophilia and have severe asthma with frequent exacerbations(1) . Surrogate biomarkers of airways inflammation have been long investigated. The importance of monitoring and managing asthma based on biomarkers is especially important for patients with discordance between symptoms and eosinophilic airway inflammation(2, 3) . Although the sputum eosinophil count has been proposed for phenotyping severe and uncontrolled asthma, it is crucial to identify a biomarker to evaluate the future risk in controlled asthma patients. This article is protected by copyright. All rights reserved.