microRNA - 200b as a switch for inducible adult angiogenesis.

Antioxidants & redox signaling

PubMedID: 25761972

Sinha M, Ghatak S, Roy S, Sen CK. microRNA - 200b as a switch for inducible adult angiogenesis. Antioxid Redox Signal. 2015;.
SIGNIFICANCE
Angiogenesis is the process by which new blood vessels develop from a pre-existing vascular system. It is required for physiological processes such as developmental biology and wound healing. Angiogenesis also plays a crucial role in pathological conditions such as tumor progression. The underlying importance of angiogenesis necessitates a highly regulated process. Recent Advances: Recent works have demonstrated that the process of angiogenesis is regulated by small non coding RNA molecules called microRNAs (miRs). These miRs, collectively referred to as angiomiRs, have been reported to have a profound effect on the process of angiogenesis by either acting as pro-angiogenic or anti-angiogenic regulators.

CRITICAL ISSUES
In this review, we will discuss the role of miR-200b as a regulator of angiogenesis. Anti-angiogenic miR-200b has been reported to provide necessary braking, once the process of angiogenesis is complete. Downregulation of miR-200b has been reported across various tumor types where deregulated angiogenesis is necessary for tumor development. Transient downregulation of miR-200b in wounds drives wound angiogenesis.

FUTURE DIRECTIONS
New insights and understanding the molecular mechanism of regulation of angiogenesis by miR-200b has opened new avenues of possible therapeutic interventions to treat angiogenesis related patho-physiological conditions.