Predominance of KPC-3 in a survey for carbapenemase-producing Enterobacteriaceae in Portugal.

Antimicrobial agents and chemotherapy

PubMedID: 25779587

Manageiro V, Ferreira E, Almeida J, Barbosa S, Simões C, ARSIP, Bonomo RA, Caniça M. Predominance of KPC-3 in a survey for carbapenemase-producing Enterobacteriaceae in Portugal. Antimicrob Agents Chemother. 2015;.
Among the 2105 Enterobacteriaceae tested in a survey done in Portugal, 165 were non-susceptible to carbapenems, from which 35 (26 Klebsiella pneumoniae, 3 Escherichia coli, 2 Enterobacter aerogenes, 3 Enterobacter cloacae and 1 Klebsiella oxytoca) were confirmed to be carbapenemase-producers, by the presence of 30 Tn4401d-blaKPC-3, 4 intI3-blaGES-5 and one intI1-blaVIM-2, alone or in combination with other bla genes. The dissemination of blaKPC-3 gene carried by an IncF plasmid suggests lateral gene transfer as a major mechanism of dissemination.