Trefoil factor family (TFF) proteins as potential serum biomarkers in patients with metastatic colorectal cancer.

Neoplasma

PubMedID: 25866228

Vocka M, Langer D, Petrtyl J, Vockova P, Hanus T, Kalousova M, Zima T, Petruzelka L. Trefoil factor family (TFF) proteins as potential serum biomarkers in patients with metastatic colorectal cancer. Neoplasma. 2015;.
Trefoil factor family (TFF) is composed of three secretory proteins (TFF1, TFF2 and TFF3) that play an important role in mucosal protection of gastrointestinal tract. Their overexpression in colorectal tumors seems to be associated with more aggressive disease. We collected serum samples from 79 healthy controls and 97 patients with metastatic colorectal cancer at the time of diagnosis or at progression. Serum levels of TTF1-3, CEA and CA19-9 were measured by ELISA. Serum TFF1 and TFF3 levels were significantly higher in patients with colorectal cancer compared to healthy controls (p?