G-quadruplex ligands exhibit differential G-tetrad selectivity.

Chemical communications (Cambridge, England)

PubMedID: 25864836

Le DD, Di Antonio M, Chan LK, Balasubramanian S. G-quadruplex ligands exhibit differential G-tetrad selectivity. Chem Commun (Camb). 2015;.
A rapid and simple equilibrium-binding assay mediated by ligand-induced fluorescence quenching of fluorophore-labelled G-quadruplex (G4) structures enabled quantitative interrogation of mutually exclusive ligand binding interactions at opposed G-tetrads. This technique revealed that the ligands TmPyP4, PhenDC3, and PDS have differential chemotype-specific binding preferences for individual G-tetrads of a model genomic G4 structure.